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Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks.

Monocrotaline is a pyrrolizidine alkaloid known to cause toxicity in humans and animals. Its mechanism of biological action is still unclear although DNA crosslinking has been suggested to a play a role in its activity. In this study we found that an active metabolite of monocrotaline, dehydromonocr...

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Udgivet i:Nucleic Acids Res
Principais autores: Pereira, T N, Webb, R I, Reilly, P E, Seawright, A A, Prakash, A S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147994/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826770/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.23.5441
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