Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.

A mouse model was generated to investigate loss of heterozygosity (LOH) events in somatic cells. The adenine phosphoribosyltransferase ( Aprt ) gene was disrupted in embryonic stem cells using a conventional gene targeting approach and subsequently Aprt hetero-zygous and homozygous mice were derived...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Van Sloun, P P, Wijnhoven, S W, Kool, H J, Slater, R, Weeda, G, van Zeeland, A A, Lohman, P H, Vrieling, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147942/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9776749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.21.4888
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