Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.
A mouse model was generated to investigate loss of heterozygosity (LOH) events in somatic cells. The adenine phosphoribosyltransferase ( Aprt ) gene was disrupted in embryonic stem cells using a conventional gene targeting approach and subsequently Aprt hetero-zygous and homozygous mice were derived...
Kaydedildi:
| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
1998
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147942/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9776749/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.21.4888 |
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