Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.

A mouse model was generated to investigate loss of heterozygosity (LOH) events in somatic cells. The adenine phosphoribosyltransferase ( Aprt ) gene was disrupted in embryonic stem cells using a conventional gene targeting approach and subsequently Aprt hetero-zygous and homozygous mice were derived...

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Bibliografiska uppgifter
Huvudupphovsmän: Van Sloun, P P, Wijnhoven, S W, Kool, H J, Slater, R, Weeda, G, van Zeeland, A A, Lohman, P H, Vrieling, H
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1998
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC147942/
https://ncbi.nlm.nih.gov/pubmed/9776749
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