लोड हो रहा है...
Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice
BACKGROUND: Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune activation. METHODS: Deglycosylated or intact C-terminal specific high affinity a...
में बचाया:
मुख्य लेखकों: | , , , , , , , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
BioMed Central
2006
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1479322/ https://ncbi.nlm.nih.gov/pubmed/16686956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-3-11 |
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