Young microglia restore amyloid plaque clearance of aged microglia

Alzheimer′s disease (AD) is characterized by deposition of amyloid plaques, neurofibrillary tangles, and neuroinflammation. In order to study microglial contribution to amyloid plaque phagocytosis, we developed a novel ex vivo model by co‐culturing organotypic brain slices from up to 20‐month‐old, a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Daria, Anna, Colombo, Alessio, Llovera, Gemma, Hampel, Heike, Willem, Michael, Liesz, Arthur, Haass, Christian, Tahirovic, Sabina
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331757/
https://ncbi.nlm.nih.gov/pubmed/28007893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694591
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