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Young microglia restore amyloid plaque clearance of aged microglia
Alzheimer′s disease (AD) is characterized by deposition of amyloid plaques, neurofibrillary tangles, and neuroinflammation. In order to study microglial contribution to amyloid plaque phagocytosis, we developed a novel ex vivo model by co‐culturing organotypic brain slices from up to 20‐month‐old, a...
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| Gepubliceerd in: | EMBO J |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5331757/ https://ncbi.nlm.nih.gov/pubmed/28007893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694591 |
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