Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

BACKGROUND: Antibodies against the Aß peptide clear Aß deposits when injected intracranially. Deglycosylated antibodies have reduced effector functions compared to their intact counterparts, potentially avoiding immune activation. METHODS: Deglycosylated or intact C-terminal specific high affinity a...

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Hlavní autoři: Carty, Niki C, Wilcock, Donna M, Rosenthal, Arnon, Grimm, Jan, Pons, Jaume, Ronan, Victoria, Gottschall, Paul E, Gordon, Marcia N, Morgan, Dave
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479322/
https://ncbi.nlm.nih.gov/pubmed/16686956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-3-11
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