Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.

Werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. The wild type Werner syndrome protein (WRN) has been demonstrated to exhibit DNA helicase activity in vitro. Here we report further biochemical characterization of the WRN he...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Shen, J C, Gray, M D, Oshima, J, Loeb, L A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147646/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611231/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2879
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