Potent inhibition of Werner and Bloom helicases by DNA minor groove binding drugs

Maintenance of genomic integrity is vital to all organisms. A number of human genetic disorders, including Werner Syndrome, Bloom Syndrome and Rothmund–Thomson Syndrome, exhibit genomic instability with some phenotypic characteristics of premature aging and cancer predisposition. Presumably the aber...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Brosh Jr, Robert M., Karow, Julia K., White, E. James, Shaw, Natalie D., Hickson, Ian D., Bohr, Vilhelm A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102731/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10871376/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.12.2420
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