Potent inhibition of Werner and Bloom helicases by DNA minor groove binding drugs

Maintenance of genomic integrity is vital to all organisms. A number of human genetic disorders, including Werner Syndrome, Bloom Syndrome and Rothmund–Thomson Syndrome, exhibit genomic instability with some phenotypic characteristics of premature aging and cancer predisposition. Presumably the aber...

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Bibliographic Details
Main Authors: Brosh Jr, Robert M., Karow, Julia K., White, E. James, Shaw, Natalie D., Hickson, Ian D., Bohr, Vilhelm A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC102731/
https://ncbi.nlm.nih.gov/pubmed/10871376
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