Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.

Werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. The wild type Werner syndrome protein (WRN) has been demonstrated to exhibit DNA helicase activity in vitro. Here we report further biochemical characterization of the WRN he...

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Dades bibliogràfiques

Publicat a:	Nucleic Acids Res
Autors principals:	Shen, J C, Gray, M D, Oshima, J, Loeb, L A
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 1998
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147646/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611231/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2879
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