Temporally and spatially regulated somatic mutagenesis in mice.

In mice transgenesis through oocyte injection or DNA recombination in embryonal stem (ES) cells allows mutations to be introduced into the germline. However, the earliest phenotype of the introduced mutation can eclipse later effects. We show in mice that site-specific genomic recombination can be i...

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Bibliografiske detaljer
Main Authors: Schwenk, F, Kuhn, R, Angrand, P O, Rajewsky, K, Stewart, A F
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC147429/
https://ncbi.nlm.nih.gov/pubmed/9490788
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