Temporally and spatially regulated somatic mutagenesis in mice.

In mice transgenesis through oocyte injection or DNA recombination in embryonal stem (ES) cells allows mutations to be introduced into the germline. However, the earliest phenotype of the introduced mutation can eclipse later effects. We show in mice that site-specific genomic recombination can be i...

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Bibliographic Details
Main Authors: Schwenk, F, Kuhn, R, Angrand, P O, Rajewsky, K, Stewart, A F
Format: Artigo
Language:Inglês
Published: 1998
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC147429/
https://ncbi.nlm.nih.gov/pubmed/9490788
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