Temporally and spatially regulated somatic mutagenesis in mice.

In mice transgenesis through oocyte injection or DNA recombination in embryonal stem (ES) cells allows mutations to be introduced into the germline. However, the earliest phenotype of the introduced mutation can eclipse later effects. We show in mice that site-specific genomic recombination can be i...

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Hlavní autoři: Schwenk, F, Kuhn, R, Angrand, P O, Rajewsky, K, Stewart, A F
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC147429/
https://ncbi.nlm.nih.gov/pubmed/9490788
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