Solution structure of a highly stable DNA duplex conjugated to a minor groove binder.

The tripeptide 1,2-dihydro-(3 H )-pyrrolo[3,2- e ]indole-7-carboxylate (CDPI3) binds to the minor groove of DNA with high affinity. When this minor groove binder is conjugated to the 5'-end of short oligonucleotides the conjugates form unusually stable hybrids with complementary DNA and thus may hav...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Kumar, S, Reed, M W, Gamper, H B, Gorn, V V, Lukhtanov, E A, Foti, M, West, J, Meyer, R B, Schweitzer, B I
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9443977/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.3.831
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