Solution structure of a highly stable DNA duplex conjugated to a minor groove binder.

The tripeptide 1,2-dihydro-(3 H )-pyrrolo[3,2- e ]indole-7-carboxylate (CDPI3) binds to the minor groove of DNA with high affinity. When this minor groove binder is conjugated to the 5'-end of short oligonucleotides the conjugates form unusually stable hybrids with complementary DNA and thus ma...

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Bibliografiske detaljer
Main Authors: Kumar, S, Reed, M W, Gamper, H B, Gorn, V V, Lukhtanov, E A, Foti, M, West, J, Meyer, R B, Schweitzer, B I
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC147317/
https://ncbi.nlm.nih.gov/pubmed/9443977
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