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Oligonucleotides with conjugated dihydropyrroloindole tripeptides: base composition and backbone effects on hybridization.

The ability of conjugated minor groove binding (MGB) residues to stabilize nucleic acid duplexes was investigated by synthesis of oligonucleotides bearing a tethered dihydropyrroloindole tripeptide (CDPI3). Duplexes bearing one or more of these conjugated MGBs were varied by base composition (AT- or...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Principais autores: Kutyavin, I V, Lukhtanov, E A, Gamper, H B, Meyer, R B
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 1997
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146950/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9278496/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.18.3718
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