Sequence-specific targeting and covalent modification of human genomic DNA.

We compare two techniques which enable selective, nucleotide-specific covalent modification of human genomic DNA, as assayed by quantitative ligation- mediated PCR. In the first, a purine motif triplex-forming oligonucleotide with a terminally appended chlorambucil was shown to label a target guanin...

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Bibliografiske detaljer
Main Authors: Belousov, E S, Afonina, I A, Podyminogin, M A, Gamper, H B, Reed, M W, Wydro, R M, Meyer, R B
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC146908/
https://ncbi.nlm.nih.gov/pubmed/9254701
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