Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.
Conjugation of an anthracycline to a triplex-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of th...
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| 發表在: | Nucleic Acids Res |
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| Principais autores: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
1997
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9153311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.11.2121 |
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