Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.

Conjugation of an anthracycline to a triplex-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of th...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Garbesi, A, Bonazzi, S, Zanella, S, Capobianco, M L, Giannini, G, Arcamone, F
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1997
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC146708/
https://ncbi.nlm.nih.gov/pubmed/9153311
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk