Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.

Conjugation of an anthracycline to a triplex-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of th...

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Bibliografski detalji
Glavni autori: Garbesi, A, Bonazzi, S, Zanella, S, Capobianco, M L, Giannini, G, Arcamone, F
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC146708/
https://ncbi.nlm.nih.gov/pubmed/9153311
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