Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.

Conjugation of an anthracycline to a triplex-forming oligonucleotide (TFO) allows delivery of this drug to a specific DNA site, preserving the intercalation geometry of this class of anticancer agents. Conjugate 11, in which the TFO is linked via a hexamethylene bridge to the O-4 on the D ring of th...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Garbesi, A, Bonazzi, S, Zanella, S, Capobianco, M L, Giannini, G, Arcamone, F
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9153311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.11.2121
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