Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased cancer incidence. The disease is caused by loss of function mutations of the WRN gene, a RecQ family member with both helicase and exonuclease activities. However, despite its...

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Autori principali: Agrelo, Ruben, Cheng, Wen-Hsing, Setien, Fernando, Ropero, Santiago, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Paz, Maria F., Sanchez-Cespedes, Montserrat, Artiga, Maria Jesus, Guerrero, David, Castells, Antoni, von Kobbe, Cayetano, Bohr, Vilhelm A., Esteller, Manel
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1466544/
https://ncbi.nlm.nih.gov/pubmed/16723399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600645103
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