Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased cancer incidence. The disease is caused by loss of function mutations of the WRN gene, a RecQ family member with both helicase and exonuclease activities. However, despite its...

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Bibliografiske detaljer
Main Authors: Agrelo, Ruben, Cheng, Wen-Hsing, Setien, Fernando, Ropero, Santiago, Espada, Jesus, Fraga, Mario F., Herranz, Michel, Paz, Maria F., Sanchez-Cespedes, Montserrat, Artiga, Maria Jesus, Guerrero, David, Castells, Antoni, von Kobbe, Cayetano, Bohr, Vilhelm A., Esteller, Manel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1466544/
https://ncbi.nlm.nih.gov/pubmed/16723399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600645103
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