Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

A defect in the Werner syndrome protein (WRN) leads to the premature aging disease Werner syndrome (WS). Hallmark features of cells derived from WS patients include genomic instability and hypersensitivity to certain DNA-damaging agents. WRN contains a highly conserved region, the RecQ conserved dom...

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Detalhes bibliográficos
Main Authors: von Kobbe, Cayetano, Harrigan, Jeanine A., May, Alfred, Opresko, Patricia L., Dawut, Lale, Cheng, Wen-Hsing, Bohr, Vilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262662/
https://ncbi.nlm.nih.gov/pubmed/14612404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8601-8613.2003
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