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Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.

HAP1 is a divalent cation-dependent endonuclease from human cells with specificity for apurinic/apyrimidinic (AP) sites in DNA. Extraction of the essential metal ion from purified HAP1 stabilized its binding to an oligonucleotide containing a single AP site, permitting AP site binding studies to be...

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Udgivet i:Nucleic Acids Res
Principais autores: Rothwell, D G, Hickson, I D
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146231/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8932375/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.21.4217
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