Effects of oligonucleotide length, mismatches and mRNA levels on C-5 propyne-modified antisense potency.

To understand the parameters required for designing potent and specific antisense C-5 propynyl-pyrimidine-2'-deoxyphosphorothioate-modified oligonucleotides (C-5 propyne ONs), we have utilized a HeLa line that stably expresses luciferase under tight control of a tetracycline-responsive promoter. Usi...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Flanagan, W M, Kothavale, A, Wagner, R W
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146034/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.2936
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