Effects of oligonucleotide length, mismatches and mRNA levels on C-5 propyne-modified antisense potency.
To understand the parameters required for designing potent and specific antisense C-5 propynyl-pyrimidine-2'-deoxyphosphorothioate-modified oligonucleotides (C-5 propyne ONs), we have utilized a HeLa line that stably expresses luciferase under tight control of a tetracycline-responsive promoter. Usi...
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| Gepubliceerd in: | Nucleic Acids Res |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
1996
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146034/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.2936 |
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