A Novel Mutation of STK11/LKB1 Gene Leads to the Loss of Cell Growth Inhibition in Head and Neck Squamous Cell Carcinoma

To investigate whether genetic alteration of the STK11/LKB1 tumor-suppressor gene is involved in the carcinogenesis of head and neck squamous cell carcinoma (HNSCC), the entire encoding exons and flanking intronic sequences of the STK11/LKB1 gene were analyzed with direct genomic sequencing of fifte...

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Bibliographic Details
Main Authors: Qiu, Wanglong, Schönleben, Frank, Thaker, Harshwardhan M., Goggins, Michael, Su., Gloria H.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459486/
https://ncbi.nlm.nih.gov/pubmed/16407837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1209325
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