Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia

The balance between bioactivation and degradation of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is critical for ensuring appropriate biological effects of vitamin D. Cytochrome P450, family 24–mediated (CYP24-mediated) 24-hydroxylation of 1,25(OH)(2)D(3 )is an important step in the catabolism of 1...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhou, Changcheng, Assem, Mahfoud, Tay, Jessica C., Watkins, Paul B., Blumberg, Bruce, Schuetz, Erin G., Thummel, Kenneth E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2006
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459072/
https://ncbi.nlm.nih.gov/pubmed/16691293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27793
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