Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation

While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to xenobiotic chemicals can impair immune function, the molecular mechanisms underlying both of these phenomena have remained larg...

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Autores principales: Zhou, Changcheng, Tabb, Michelle M., Nelson, Edward L., Grün, Felix, Verma, Suman, Sadatrafiei, Asal, Lin, Min, Mallick, Shyamali, Forman, Barry M., Thummel, Kenneth E., Blumberg, Bruce
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501109/
https://ncbi.nlm.nih.gov/pubmed/16841097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26283
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