Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation

While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and that exposure to xenobiotic chemicals can impair immune function, the molecular mechanisms underlying both of these phenomena have remained larg...

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Autors principals: Zhou, Changcheng, Tabb, Michelle M., Nelson, Edward L., Grün, Felix, Verma, Suman, Sadatrafiei, Asal, Lin, Min, Mallick, Shyamali, Forman, Barry M., Thummel, Kenneth E., Blumberg, Bruce
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501109/
https://ncbi.nlm.nih.gov/pubmed/16841097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26283
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