Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and...

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Bibliografiske detaljer
Main Authors: Tabb, Michelle M, Kholodovych, Vladyslav, Grün, Felix, Zhou, Changcheng, Welsh, William J, Blumberg, Bruce
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1241825/
https://ncbi.nlm.nih.gov/pubmed/14754570
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