The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)

Platelet production is induced by the cytokine thrombopoietin (TPO). It is physiologically critical that TPO expression is tightly regulated, because lack of TPO causes life-threatening thrombocytopenia while an excess of TPO results in thrombocytosis. The plasma concentration of TPO is controlled b...

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Bibliographic Details
Main Authors: Stockklausner, Clemens, Breit, Stephen, Neu-Yilik, Gabriele, Echner, Nicole, Hentze, Matthias W., Kulozik, Andreas E., Gehring, Niels H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458284/
https://ncbi.nlm.nih.gov/pubmed/16679454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl277
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