Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

We identified Caspase-8 as a new substrate for Src kinase. Phosphorylation occurs on Tyr380, situated in the linker region between the large and the small subunits of human Procaspase-8, and results in downregulation of Caspase-8 proapoptotic function. Src activation triggers Caspase-8 phosphorylati...

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Bibliografski detalji
Glavni autori: Cursi, Silvia, Rufini, Alessandra, Stagni, Venturina, Condò, Ivano, Matafora, Vittoria, Bachi, Angela, Bonifazi, Antonio Paniccià, Coppola, Luigi, Superti-Furga, Giulio, Testi, Roberto, Barilà, Daniela
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456929/
https://ncbi.nlm.nih.gov/pubmed/16619028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601085
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