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Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression
We identified Caspase-8 as a new substrate for Src kinase. Phosphorylation occurs on Tyr380, situated in the linker region between the large and the small subunits of human Procaspase-8, and results in downregulation of Caspase-8 proapoptotic function. Src activation triggers Caspase-8 phosphorylati...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456929/ https://ncbi.nlm.nih.gov/pubmed/16619028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601085 |
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