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Identification of a Critical Tyrosine Residue in Caspase 8 That Promotes Cell Migration

Caspase 8 is a critical upstream initiator of programmed cell death but, paradoxically, has also been shown to promote cell migration. Here, we show that tyrosine 380 in the linker loop of human caspase 8 is a critical switch determining caspase 8 function. Our studies show that, in addition to its...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Barbero, Simone, Barilà, Daniela, Mielgo, Ainhoa, Stagni, Venturina, Clair, Kiran, Stupack, Dwayne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442311/
https://ncbi.nlm.nih.gov/pubmed/18216014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800549200
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