Cleavage of the siRNA passenger strand during RISC assembly in human cells

A crucial step in the RNA interference (RNAi) pathway involves the assembly of RISC, the RNA-induced silencing complex. RISC initially recognizes a double-stranded short interfering RNA (siRNA), but only one strand is finally retained in the functional ribonucleoprotein complex. The non-incorporated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Leuschner, Philipp J F, Ameres, Stefan L, Kueng, Stephanie, Martinez, Javier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456892/
https://ncbi.nlm.nih.gov/pubmed/16439995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400637
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