Genetic Instability Induced by Overexpression of DNA Ligase I in Budding Yeast

Recombination and microsatellite mutation in humans contribute to disorders including cancer and trinucleotide repeat (TNR) disease. TNR expansions in wild-type yeast may arise by flap ligation during lagging-strand replication. Here we show that overexpression of DNA ligase I (CDC9) increases the r...

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Hlavní autoři: Subramanian, Jaichandar, Vijayakumar, Sangeetha, Tomkinson, Alan E., Arnheim, Norman
Médium: Artigo
Jazyk:Inglês
Vydáno: Copyright © 2005 by the Genetics Society of America 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456761/
https://ncbi.nlm.nih.gov/pubmed/15965249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.042861
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