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Genetic Instability Induced by Overexpression of DNA Ligase I in Budding Yeast
Recombination and microsatellite mutation in humans contribute to disorders including cancer and trinucleotide repeat (TNR) disease. TNR expansions in wild-type yeast may arise by flap ligation during lagging-strand replication. Here we show that overexpression of DNA ligase I (CDC9) increases the r...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Copyright © 2005 by the Genetics Society of America
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456761/ https://ncbi.nlm.nih.gov/pubmed/15965249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.042861 |
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