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The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation

Unfolding is an essential process during translocation of preproteins into mitochondria; however, controversy exists as to whether mitochondria play an active role in unfolding. We have established an in vitro system with a kinetic saturation of the mitochondrial import machinery, yielding transloca...

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Udgivet i:EMBO J
Principais autores: Lim, Joo Hyun, Martin, Falk, Guiard, Bernard, Pfanner, Nikolaus, Voos, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145481/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11230118/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.5.941
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