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Optimization of Amide-Based Inhibitors of Soluble Epoxide Hydrolase with Improved Water Solubility
Soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation. 1,3-Disubstituted ureas with a polar group located on the fifth atom from the carbonyl group of urea function are active inhibitor...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450255/ https://ncbi.nlm.nih.gov/pubmed/15887969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0500929 |
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