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Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast
Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are heterozygous for a loss-of-function allele. Despite its relevance to human disease, neither the extent of haploinsufficiency nor its precise molecular mechanisms are well understood. We used the complete set of Sacch...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Genetics Society of America
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1449596/ https://ncbi.nlm.nih.gov/pubmed/15716499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.036871 |
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