Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast

Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are heterozygous for a loss-of-function allele. Despite its relevance to human disease, neither the extent of haploinsufficiency nor its precise molecular mechanisms are well understood. We used the complete set of Sacch...

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Detaylı Bibliyografya
Asıl Yazarlar: Deutschbauer, Adam M., Jaramillo, Daniel F., Proctor, Michael, Kumm, Jochen, Hillenmeyer, Maureen E., Davis, Ronald W., Nislow, Corey, Giaever, Guri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Genetics Society of America 2005
Konular:
Investigations
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449596/
https://ncbi.nlm.nih.gov/pubmed/15716499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.036871
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