Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

We systematically analyzed the relationships between gene fitness profiles (co-fitness) and drug inhibition profiles (co-inhibition) from several hundred chemogenomic screens in yeast. Co-fitness predicted gene functions distinct from those derived from other assays and identified conditionally depe...

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Huvudupphovsmän: Hillenmeyer, Maureen E, Ericson, Elke, Davis, Ronald W, Nislow, Corey, Koller, Daphne, Giaever, Guri
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864570/
https://ncbi.nlm.nih.gov/pubmed/20226027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-3-r30
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