Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function

We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and stroke. These inhibitors are believed to exert both their beneficial and their adverse effects by suppression of PGHS-2–derived...

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Bibliographic Details
Main Authors: Cheng, Yan, Wang, Miao, Yu, Ying, Lawson, John, Funk, Colin D., FitzGerald, Garret A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435722/
https://ncbi.nlm.nih.gov/pubmed/16614756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27540
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