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Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse

Reversible transcriptional silencing of genes located near telomeres, termed the telomere position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been observed in human tumor cell lines, but its function remains unknown. To investigate TPE in normal mammalian cells, we...

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Main Authors: Pedram, Mehrdad, Sprung, Carl N., Gao, Qing, Lo, Anthony W. I., Reynolds, Gloria E., Murnane, John P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430234/
https://ncbi.nlm.nih.gov/pubmed/16479005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.5.1865-1878.2006
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