Exposure of Lymphocytes to High Doses of Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin Induces Rapid Onset of Apoptosis-Mediated DNA Fragmentation

We have shown previously that treatment of human lymphocytes with the Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt) results in dose-dependent G(2) arrest, followed 24 h later by apoptotic cell death. Here we demonstrated that for Jurkat cells exposed to high concentrations o...

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Hlavní autoři: Shenker, Bruce J., Demuth, Donald R., Zekavat, Ali
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418899/
https://ncbi.nlm.nih.gov/pubmed/16552037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.4.2080-2092.2006
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