Single Nucleotide Polymorphism in the Cytolethal Distending Toxin B Gene Confers Heterogeneity in the Cytotoxicity of Actinobacillus actinomycetemcomitans

Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantl...

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Bibliographic Details
Main Authors: Nishikubo, Shuichi, Ohara, Masaru, Ikura, Masae, Katayanagi, Katsuo, Fujiwara, Tamaki, Komatsuzawa, Hitoshi, Kurihara, Hidemi, Sugai, Motoyuki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698065/
https://ncbi.nlm.nih.gov/pubmed/16982823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02063-05
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