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CdtC-Induced Processing of Membrane-Bound CdtA Is a Crucial Step in Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Holotoxin Formation

Aggregatibacter actinomycetemcomitans is an oral pathogen causing periodontal disease and bacterial endocarditis. It produces cytolethal distending toxin (CDT) that could damage mammalian cells and tissues. CDT is a tripartite protein toxin composed of CdtA, CdtB, and CdtC. We have previously indica...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Tsuruda, Keiko, Matangkasombut, Oranart, Ohara, Masaru, Sugai, Motoyuki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820955/
https://ncbi.nlm.nih.gov/pubmed/29229729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00731-17
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