Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins

Cytolethal distending toxins (CDTs) are heterotrimeric protein exotoxins produced by a diverse array of Gram-negative pathogens. The enzymatic subunit, CdtB, possesses DNase and phosphatidylinositol 3-4-5 trisphosphate phosphatase activities that induce host cell cycle arrest, cellular distension an...

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Udgivet i:PLoS One
Main Authors: Dixon, Shandee D., Huynh, Melanie M., Tamilselvam, Batcha, Spiegelman, Lindsey M., Son, Sophia B., Eshraghi, Aria, Blanke, Steven R., Bradley, Kenneth A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664275/
https://ncbi.nlm.nih.gov/pubmed/26618479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143977
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