Interactions of Campylobacter jejuni Cytolethal Distending Toxin Subunits CdtA and CdtC with HeLa Cells

Campylobacter jejuni produces a toxin, called cytolethal distending toxin (CDT), which causes direct DNA damage leading to invocation of DNA damage checkpoint pathways. The affected cells arrest in G(1) or G(2) and eventually die. CDT consists of three protein subunits, CdtA, CdtB, and CdtC, with Cd...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Robert B., Hassane, Duane C., Cottle, Daniel L., Pickett, Carol L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC187314/
https://ncbi.nlm.nih.gov/pubmed/12933829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.9.4883-4890.2003
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